Conserved Protein Domain Family
G-patch_2
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pfam12656: G-patch_2 
G-patch domain
Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.
Links
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Statistics
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PSSM-Id: 432700
Aligned: 55 rows
Threshold Bit Score: 50.3541
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002293329 260 AADVDPTsnVYANVSIGDFGSA--LLRGMGWNgsaSGNINNNgnsrlgggakrlggskptdEEVIKPRPH-RLGLGATPL 336
A0EB76        19 PDNTEDT---YSKAPVSQFAQN--LLSKMGFQe--GQPIGKNsqkss----------allkPIEFLSRGD-REGLGVNPM 80  Paramecium tetr...
Q10NZ4       169 PDHRGLD--EFRDVPVEGFGAA--LLAGYGWSe--GKGIGRNnkg-------------dtkVVEYDRRAG-TQGLGYNPS 228 Japanese rice
Q9C801       143 ADDPTLE--DFESVPVDGFGAA--LMAGYGWKp--GKGIGKNake-------------dveIKEYKKWTA-KEGLGFDPD 202 thale cress
XP_011028014 134 PEDRGFE--EFEEMPVEDFAKA--LLKGYGWHe--GRGVGKNske-------------dvqVKQYTKRTD-KEGLGFLAA 193
EEF39428     144 PEDRGFD--EFKDVPVEGFGAA--LLAGYGWRe--GRGIGRNake-------------dvkVKQYTKRTD-KEGLGFVAS 203
EEC04522     737 PMPAQQNyeEPTKAGIGEDNIGnkMLKAMGWSe--GQGLGKSntg-------------ttnIVEVQRRVT-SAGLGVRGA 800
EDO48869     461 PASEVAVaqATLPIPEHNIGNQ--MLREMGWVp--GKGLGPNqsg-------------rvdPVKATMRPK-GLGLGHTWP 522
EDO05339     210 DHEDTDVepSYENVAVEEFGLA--MLLGMGFNp--ATNTNKPk--------------------EYKRRAYdRAGLGADAH 265
ESS29474     334 PDALSATsaEYSRIPVSEFGLA--MLRGMGYDa--EKKEETTkg-----------------aAPKRKRTYnRAGLGSEEE 392

XP_002293329 337 P 337
A0EB76        81 K 81  Paramecium tetraurelia
Q10NZ4       229 E 229 Japanese rice
Q9C801       203 R 203 thale cress
XP_011028014 194 S 194
EEF39428     204 V 204
EEC04522     801 T 801
EDO48869     523 S 523
EDO05339     266 M 266
ESS29474     393 V 393
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