2X7O: Crystal structure of TGFbRI complexed with an indolinone inhibitor

PDB ID: 2X7ODownload
MMDB ID: 85562
PDB Deposition Date: 2010/3/3
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 3.7  Å
Source Organism:
Similar Structures:
Biological Unit for 2X7O: monomeric; determined by author and by software (PISA)
Molecular Components in 2X7O
Label Count Molecule
Protein (1 molecule)
1
Tgf-beta Receptor Type I
(Gene symbol: TGFBR1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(3Z)-N-ETHYL-N-METHYL-2-OXO-3-(PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-6-CARBOXAMIDE(3Z)-N-ETHYL-N-METHYL-2-OXO-3-(PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-6-CARBOXAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303