2YAC: Crystal structure of Polo-like kinase 1 in complex with NMS-P937

PDB ID: 2YACDownload
MMDB ID: 89646
PDB Deposition Date: 2011/2/18
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 2YAC: dimeric; determined by author and by software (PISA)
Molecular Components in 2YAC
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase Plk1
(Gene symbol: PLK1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE
2
2
ZINC IONZINC ION
3
2
L(+)-TARTARIC ACIDL(+)-TARTARIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303