2ZIS: Crystal Structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and FPP

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PDB ID: 2ZISDownload
MMDB ID: 69787
PDB Deposition Date: 2008/2/22
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 2ZIS: dimeric; determined by author and by software (PISA)
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2ZIS: Crystal Structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and FPP
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Interactions?
AA: Protein farnesyltransferase subunit alphaBB: Protein farnesyltransferase subunit beta1ACY: ACETIC ACID2ZN: ZINC ION3FPP: FARNESYL DIPHOSPHATE4NH8: 3-{2-[(S)-(4-cyanophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-5-nitro-1-benzofuran-7-yl}benzonitrile1ACY: ACETIC ACID5GOL: GLYCEROL5GOL: GLYCEROL5GOL: GLYCEROL66: 66: 66:
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Molecular Components in 2ZIS
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase Subunit Alpha
(Gene symbol: Fnta)
1 Protein
SS Diagram
3D Domains
Domain Families
Super Families
1100200300377377 residues, click to see VAST similar structures.helix 94-109helix 114-126helix 131-144helix 148-161helix 167-179helix 185-195helix 200-213helix 219-229helix 234-247helix 253-269helix 275-284helix 309-325helix 330-346helix 353-366Domain 1 (1-146): click to see VAST similar structures1Domain 2 (147-216): click to see VAST similar structures2Domain 3 (217-296): click to see VAST similar structures3Domain 4 (297-377): click to see VAST similar structures4PLN02789 superfamilycl33568(64-365): farnesyltranstransferase
1
Protein Farnesyltransferase Subunit Beta
(Gene symbol: Fntb)
1 Protein
SS Diagram
3D Domains
Features
Domain Families
Specific Hits
Super Families
1100200300400440440 residues, click to see VAST similar structures.helix 46-63helix 78-90helix 103-117helix 123-136helix 153-166helix 177-186helix 205-217helix 252-265helix 273-282helix 311-321helix 335-344helix 363-376helix 408-418strand 187-190strand 192-195strand 235-238strand 240-243strand 346-349strand 351-354strand 377-382strand 383-388Domain 1 (71-171): click to see VAST similar structures1Domain 2 (172-328): click to see VAST similar structures2Domain 1 (329-398): click to see VAST similar structures1Domain 2 (399-440): click to see VAST similar structures2active site cavityactive site(23)location: 98, residue: Clocation: 101, residue: Alocation: 102, residue: Slocation: 105, residue: Wlocation: 109, residue: Wlocation: 152, residue: Hlocation: 154, residue: Alocation: 155, residue: Plocation: 157, residue: Ylocation: 158, residue: Alocation: 205, residue: Rlocation: 208, residue: Ylocation: 209, residue: Clocation: 251, residue: Hlocation: 253, residue: Glocation: 257, residue: Clocation: 300, residue: Dlocation: 302, residue: Clocation: 303, residue: Ylocation: 306, residue: Wlocation: 355, residue: Dlocation: 364, residue: Ylocation: 365, residue: HZn2+ binding siteZn2+ binding site(3)location: 300, residue: Dlocation: 302, residue: Clocation: 365, residue: Hlipid binding pocketlipid binding(12)location: 105, residue: Wlocation: 108, residue: Ylocation: 205, residue: Rlocation: 208, residue: Ylocation: 251, residue: Hlocation: 253, residue: Glocation: 257, residue: Clocation: 294, residue: Rlocation: 297, residue: Klocation: 303, residue: Ylocation: 306, residue: Wlocation: 364, residue: Ypeptide binding pocketpeptide(8)location: 101, residue: Alocation: 102, residue: Slocation: 105, residue: Wlocation: 154, residue: Alocation: 155, residue: Plocation: 205, residue: Rlocation: 300, residue: Dlocation: 355, residue: Dheterodimer interfaceheterodimer interface(12)location: 200, residue: Glocation: 238, residue: Wlocation: 248, residue: Mlocation: 249, residue: Elocation: 254, residue: Ylocation: 278, residue: Qlocation: 281, residue: Tlocation: 283, residue: Rlocation: 284, residue: Qlocation: 294, residue: Rlocation: 295, residue: Clocation: 296, residue: NFTasecd02893 (78-376): Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold)ISOPREN_C2_like superfamilycl08267(78-376): This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2...
Chemicals and Non-standard biopolymers (11 molecules)
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