2ZM4: Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394)

PDB ID: 2ZM4Download
MMDB ID: 67310
PDB Deposition Date: 2008/4/11
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 2ZM4: monomeric; determined by author and by software (PISA)
Molecular Components in 2ZM4
Label Count Molecule
Protein (1 molecule)
1
Proto-oncogene Tyrosine-protein Kinase LCK
(Gene symbol: LCK)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
SULFATE IONSULFATE ION
2
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amineN-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303