3AC1: Crystal structure of pyrazin derivative bound to the kinase domain of Human LCK, (Auto-phosphorylated on TYR394)

PDB ID: 3AC1Download
MMDB ID: 83021
PDB Deposition Date: 2009/12/28
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.99  Å
Source Organism:
Similar Structures:
Biological Unit for 3AC1: monomeric; determined by author and by software (PISA)
Molecular Components in 3AC1
Label Count Molecule
Protein (1 molecule)
1
Proto-oncogene Tyrosine-protein Kinase LCK
(Gene symbol: LCK)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
SULFATE IONSULFATE ION
2
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
4
1
5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-[(3,5-dimethoxyphenyl)amino]pyrazine-2-carboxamide5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-[(3,5-dimethoxyphenyl)amino]pyrazine-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303