3CL9: Structure of bifunctional TcDHFR-TS in complex with MTX

PDB ID: 3CL9Download
MMDB ID: 68862
PDB Deposition Date: 2008/3/18
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 3CL9: dimeric; determined by author and by software (PISA)
Molecular Components in 3CL9
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Dihydrofolate Reductase-thymidylate Synthase (Dhfr-ts)
Molecule annotation
Chemicals and Non-standard biopolymers (20 molecules)
1
4
SULFATE IONSULFATE ION
2
6
CHLORIDE IONCHLORIDE ION
3
2
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
4
2
METHOTREXATEMETHOTREXATE
5
2
2'-DEOXYURIDINE 5'-MONOPHOSPHATE2'-DEOXYURIDINE 5'-MONOPHOSPHATE
6
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303