3DPY: Protein farnesyltransferase complexed with FPP and caged TKCVIM substrate

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PDB ID: 3DPYDownload
MMDB ID: 67041
PDB Deposition Date: 2008/7/9
Updated in MMDB: 2008/10
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 3DPY: trimeric; determined by author and by software (PISA)
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3DPY: Protein farnesyltransferase complexed with FPP and caged TKCVIM substrate
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AA: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaBB: Protein farnesyltransferase subunit betaCC: caged substrate1ZN: ZINC ION2FPP: FARNESYL DIPHOSPHATE3ACY: ACETIC ACID
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Molecular Components in 3DPY
Label Count Molecule
Proteins (3 molecules)
1
Protein Farnesyltransferase/geranylgeranyltransferase Type-1 Subunit Alpha
1 Protein
SS Diagram
3D Domains
Domain Families
Super Families
175150225300377377 residues, click to see VAST similar structures.helix 94-109helix 114-126helix 131-144helix 148-161helix 168-179helix 185-195helix 200-213helix 219-229helix 234-246helix 253-269helix 275-284helix 294-302helix 309-325helix 330-346helix 353-366Domain 1 (1-146): click to see VAST similar structures1Domain 2 (147-216): click to see VAST similar structures2Domain 3 (217-289): click to see VAST similar structures3Domain 4 (290-377): click to see VAST similar structures4PLN02789 superfamilycl33568(64-365): farnesyltranstransferase
1
Protein Farnesyltransferase Subunit Beta
1 Protein
SS Diagram
3D Domains
Features
Domain Families
Specific Hits
Super Families
175150225300375437437 residues, click to see VAST similar structures.helix 43-60helix 75-86helix 100-114helix 120-133helix 151-163helix 174-183helix 202-214helix 249-262helix 270-279helix 308-318helix 332-341helix 360-373helix 405-415strand 184-187strand 189-192strand 232-235strand 237-240strand 343-346strand 348-351strand 374-379strand 380-385Domain 1 (68-168): click to see VAST similar structures1Domain 2 (169-325): click to see VAST similar structures2Domain 1 (326-395): click to see VAST similar structures1Domain 2 (396-437): click to see VAST similar structures2active site cavityactive site(23)location: 95, residue: Clocation: 98, residue: Alocation: 99, residue: Slocation: 102, residue: Wlocation: 106, residue: Wlocation: 149, residue: Hlocation: 151, residue: Alocation: 152, residue: Plocation: 154, residue: Ylocation: 155, residue: Alocation: 202, residue: Rlocation: 205, residue: Ylocation: 206, residue: Clocation: 248, residue: Hlocation: 250, residue: Glocation: 254, residue: Clocation: 297, residue: Dlocation: 299, residue: Clocation: 300, residue: Ylocation: 303, residue: Wlocation: 352, residue: Dlocation: 361, residue: Ylocation: 362, residue: HZn2+ binding siteZn2+ binding site(3)location: 297, residue: Dlocation: 299, residue: Clocation: 362, residue: Hlipid binding pocketlipid binding(12)location: 102, residue: Wlocation: 105, residue: Ylocation: 202, residue: Rlocation: 205, residue: Ylocation: 248, residue: Hlocation: 250, residue: Glocation: 254, residue: Clocation: 291, residue: Rlocation: 294, residue: Klocation: 300, residue: Ylocation: 303, residue: Wlocation: 361, residue: Ypeptide binding pocketpeptide(8)location: 98, residue: Alocation: 99, residue: Slocation: 102, residue: Wlocation: 151, residue: Alocation: 152, residue: Plocation: 202, residue: Rlocation: 297, residue: Dlocation: 352, residue: Dheterodimer interfaceheterodimer interface(12)location: 197, residue: Glocation: 235, residue: Wlocation: 245, residue: Mlocation: 246, residue: Elocation: 251, residue: Ylocation: 275, residue: Qlocation: 278, residue: Tlocation: 280, residue: Rlocation: 281, residue: Qlocation: 291, residue: Rlocation: 292, residue: Clocation: 293, residue: NFTasecd02893 (75-373): Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold)ISOPREN_C2_like superfamilycl08267(75-373): This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2...
1
Caged Substrate
166 residues, click to see VAST similar structures.
Chemicals and Non-standard biopolymers (3 molecules)
1
1
1
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