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3E30:
Protein farnesyltransferase complexed with FPP and ethylene diamine inhibitor 4
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PDB ID:
3E30
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MMDB ID:
70115
PDB Deposition Date:
2008/8/6
Updated in MMDB:
2011/05
Experimental Method:
x-ray diffraction
Resolution:
2.45 Å
Source Organism:
Rattus norvegicus
Similar Structures:
VAST+
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Default Biological Unit
All Biological Units (3)
Asymmetric Unit
Biological Unit for 3E30: monomeric; determined by author
Molecular Graphic
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Interactions
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A
A: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
1
FPP: FARNESYL DIPHOSPHATE
2
ED4: tert-butyl 4-({(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}methyl)piperidine-1-carboxylate
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Format:
ASN.1 (Cn3D)
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Data Set:
alpha-Carbons
Single 3D structure
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Molecular Components in 3E30
Label
Count
Molecule
Protein (1 molecule)
A
1
Protein Farnesyltransferase/geranylgeranyltransferase Type-1 Subunit Alpha
(Gene symbol:
Fnta
)
1 Protein
SS Diagram
3D Domains
Domain Families
Super Families
1
75
150
225
300
377
377 residues, click to see VAST similar structures.
helix 94-109
helix 114-126
helix 131-144
helix 148-161
helix 167-179
helix 186-195
helix 200-213
helix 219-229
helix 234-246
helix 253-269
helix 275-284
helix 295-302
helix 309-325
helix 330-346
helix 353-366
Domain 1 (1-146): click to see VAST similar structures
1
Domain 2 (147-216): click to see VAST similar structures
2
Domain 3 (217-289): click to see VAST similar structures
3
Domain 4 (290-377): click to see VAST similar structures
4
PLN02789 superfamily
cl33568(64-365): farnesyltranstransferase
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Chemicals and Non-standard biopolymers (2 molecules)
1
1
FARNESYL DIPHOSPHATE
2
1
tert-butyl 4-({(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}methyl)piperidine-1-carboxylate
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Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303
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