3E5A: Crystal structure of Aurora A in complex with VX-680 and TPX2

PDB ID: 3E5ADownload
MMDB ID: 67642
PDB Deposition Date: 2008/8/13
Updated in MMDB: 2012/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 3E5A: dimeric; determined by author and by software (PISA)
Molecular Components in 3E5A
Label Count Molecule
Proteins (2 molecules)
1
Serine/threonine-protein Kinase 6
(Gene symbol: AURKA)
Molecule annotation
1
Targeting Protein for Xklp2
(Gene symbol: TPX2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDECYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE
2
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303