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3EU5:
Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BiotinGPP
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PDB ID:
3EU5
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MMDB ID:
75135
PDB Deposition Date:
2008/10/9
Updated in MMDB:
2023/11
Experimental Method:
x-ray diffraction
Resolution:
2.8 Å
Source Organism:
Rattus norvegicus
Similar Structures:
VAST+
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Biological Unit
Asymmetric Unit
Biological Unit for 3EU5: dimeric; determined by author and by software (PISA)
Molecular Graphic
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Interactions
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A
A: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
B
B: Protein farnesyltransferase subunit beta
1
ZN: ZINC ION
2
GBO: (2E,6E)-3,7-dimethyl-8-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octa-2,6-dien-1-yl trihydrogen diphosphate
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Format:
ASN.1 (Cn3D)
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Data Set:
alpha-Carbons
Single 3D structure
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Molecular Components in 3EU5
Label
Count
Molecule
Proteins (2 molecules)
A
1
Protein Farnesyltransferase/geranylgeranyltransferase Type-1 Subunit Alpha
(Gene symbol:
Fnta
)
1 Protein
SS Diagram
3D Domains
1
75
150
225
300
377
377 residues, click to see VAST similar structures.
helix 94-109
helix 114-126
helix 131-144
helix 149-161
helix 167-179
helix 186-195
helix 200-213
helix 219-229
helix 234-247
helix 253-269
helix 275-284
helix 295-302
helix 309-325
helix 330-346
helix 353-366
Domain 1 (1-146): click to see VAST similar structures
1
Domain 2 (147-216): click to see VAST similar structures
2
Domain 3 (217-289): click to see VAST similar structures
3
Domain 4 (290-377): click to see VAST similar structures
4
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B
1
Protein Farnesyltransferase Subunit Beta
(Gene symbol:
Fntb
)
1 Protein
SS Diagram
3D Domains
1
75
150
225
300
375
427
427 residues, click to see VAST similar structures.
helix 43-63
helix 75-87
helix 100-114
helix 120-132
helix 151-163
helix 174-183
helix 202-214
helix 249-262
helix 270-279
helix 308-318
helix 332-341
helix 360-373
helix 405-416
strand 133-136
strand 138-141
strand 184-187
strand 189-192
strand 232-235
strand 237-240
strand 343-346
strand 348-351
strand 374-379
strand 380-385
Domain 1 (70-183): click to see VAST similar structures
1
Domain 2 (184-325): click to see VAST similar structures
2
Domain 1 (326-395): click to see VAST similar structures
1
Domain 2 (396-427): click to see VAST similar structures
2
click domain graphic to toggle highlight of corresponding residues in 3D viewer
Chemicals and Non-standard biopolymers (2 molecules)
1
1
ZINC ION
2
1
(2E,6E)-3,7-dimethyl-8-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octa-2,6-dien-1-yl trihydrogen diphosphate
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Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303
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