3TH3: Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+

PDB ID: 3TH3Download
MMDB ID: 158799
PDB Deposition Date: 2011/8/18
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 3TH3: trimeric; determined by author and by software (PISA)
Molecular Components in 3TH3
Label Count Molecule
Proteins (3 molecules)
1
Coagulation Factor VII Light Chain
(Gene symbol: F7)
Molecule annotation
1
Coagulation Factor VII Heavy Chain
(Gene symbol: F7)
Molecule annotation
1
Tissue Factor
(Gene symbol: F3)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
alpha-L-fucopyranosealpha-L-fucopyranose
2
2
CALCIUM IONCALCIUM ION
3
1
beta-D-glucopyranosebeta-D-glucopyranose
4
1
N-{[5-(dimethylamino)naphthalen-1-yl]sulfonyl}-L-alpha-glutamyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]glycinamideN-{[5-(dimethylamino)naphthalen-1-yl]sulfonyl}-L-alpha-glutamyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]glycinamide
5
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303