4DQM: Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity

PDB ID: 4DQMDownload
MMDB ID: 103531
PDB Deposition Date: 2012/2/16
Updated in MMDB: 2018/11
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
Similar Structures:
Biological Unit for 4DQM: dimeric; determined by author and by software (PISA)
Molecular Components in 4DQM
Label Count Molecule
Proteins (2 molecules)
1
Retinoic Acid Receptor Alpha
(Gene symbol: RARA)
Molecule annotation
1
Nuclear Receptor Coactivator 1
(Gene symbol: NCOA1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one(5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303