4MDD: Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12

PDB ID: 4MDDDownload
MMDB ID: 125180
PDB Deposition Date: 2013/8/22
Updated in MMDB: 2014/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4MDD: tetrameric; determined by software (PISA)
Molecular Components in 4MDD
Label Count Molecule
Proteins (4 molecules)
2
Glucocorticoid Receptor
(Gene symbol: NR3C1)
Molecule annotation
2
Nuclear Receptor Corepressor 1
(Gene symbol: NCOR1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamideN-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303