4MPE: Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS8

PDB ID: 4MPEDownload
MMDB ID: 116401
PDB Deposition Date: 2013/9/12
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 1.953  Å
Source Organism:
Similar Structures:
Biological Unit for 4MPE: dimeric; determined by author and by software (PISA)
Molecular Components in 4MPE
Label Count Molecule
Proteins (2 molecules)
2
[pyruvate Dehydrogenase [lipoamide]] Kinase Isozyme 2, Mitochondrial
(Gene symbol: PDK2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
4-[(5-hydroxy-1,3-dihydro-2H-isoindol-2-yl)sulfonyl]benzene-1,3-diol4-[(5-hydroxy-1,3-dihydro-2H-isoindol-2-yl)sulfonyl]benzene-1,3-diol
2
2
L(+)-TARTARIC ACIDL(+)-TARTARIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303