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4O0T:
Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
PDB ID:
4O0T
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MMDB ID:
117540
PDB Deposition Date:
2013/12/14
Updated in MMDB:
2024/03
Experimental Method:
x-ray diffraction
Resolution:
2.6 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4O0T: monomeric; determined by author
Molecular Components in 4O0T
Label
Count
Molecule
Protein (1 molecule)
A
1
Serine/threonine-protein Kinase PAK 1
(Gene symbol:
PAK1
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
1-({1-(2-aminopyrimidin-4-yl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl}ethynyl)cyclohexanol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303