4O0T: Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors

PDB ID: 4O0TDownload
MMDB ID: 117540
PDB Deposition Date: 2013/12/14
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4O0T: monomeric; determined by author
Molecular Components in 4O0T
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase PAK 1
(Gene symbol: PAK1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
1-({1-(2-aminopyrimidin-4-yl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl}ethynyl)cyclohexanol1-({1-(2-aminopyrimidin-4-yl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl}ethynyl)cyclohexanol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303