4U42: MAP4K4 T181E Mutant Bound to inhibitor compound 1

PDB ID: 4U42Download
MMDB ID: 135257
PDB Deposition Date: 2014/7/23
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.504  Å
Source Organism:
Similar Structures:
Biological Unit for 4U42: dimeric; determined by author and by software (PISA)
Molecular Components in 4U42
Label Count Molecule
Proteins (2 molecules)
2
Mitogen-activated Protein Kinase Kinase Kinase Kinase 4
(Gene symbol: MAP4K4)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
2
2
6-[(3S)-3-(4-methyl-1H-pyrazol-3-yl)piperidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine6-[(3S)-3-(4-methyl-1H-pyrazol-3-yl)piperidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine
3
2
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303