4WKI: Crystal structure of human ADAMTS-4 in complex with inhibitor 5-CHLORO-N-{[(4S)-4-(1-METHYL-1H-IMIDAZOL-2-YL)-2,5-DIOXOIMIDAZOLIDIN-4-YL]METHYL}-1-BENZOFURAN-2-CARBOXAMIDE (compound 11)

PDB ID: 4WKIDownload
MMDB ID: 125525
PDB Deposition Date: 2014/10/2
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4WKI: monomeric; determined by author and by software (PISA)
Molecular Components in 4WKI
Label Count Molecule
Protein (1 molecule)
1
a Disintegrin and Metalloproteinase With Thrombospondin Motifs 4
(Gene symbol: ADAMTS4)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
ZINC IONZINC ION
2
3
CALCIUM IONCALCIUM ION
3
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
5-chloro-N-{[(4S)-4-(1-methyl-1H-imidazol-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl}-1-benzofuran-2-carboxamide5-chloro-N-{[(4S)-4-(1-methyl-1H-imidazol-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl}-1-benzofuran-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303