4YWY: Crystal Structure of double mutant Y115E Y117E human Glutaminyl Cyclase in complex with inhibitor PBD-150

PDB ID: 4YWYDownload
MMDB ID: 131475
PDB Deposition Date: 2015/3/21
Updated in MMDB: 2015/08
Experimental Method:
x-ray diffraction
Resolution: 1.95  Å
Source Organism:
Similar Structures:
Biological Unit for 4YWY: monomeric; determined by author
Molecular Components in 4YWY
Label Count Molecule
Protein (1 molecule)
1
Glutaminyl-peptide Cyclotransferase
(Gene symbol: QPCT)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
1
ZINC IONZINC ION
2
1
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
3
7
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
2
SULFATE IONSULFATE ION
5
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303