5A63: Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution

PDB ID: 5A63Download
MMDB ID: 131510
PDB Deposition Date: 2015/6/24
Updated in MMDB: 2016/12
Experimental Method:
electron microscopy
Resolution: 3.4  Å
Source Organism:
Similar Structures:
Biological Unit for 5A63: tetrameric; determined by software (PISA)
Molecular Components in 5A63
Label Count Molecule
Proteins (4 molecules)
1
Nicastrin
(Gene symbol: NCSTN)
Molecule annotation
1
Presenilin-1
(Gene symbol: PSEN1)
Molecule annotation
1
Gamma-secretase Subunit Aph-1a
(Gene symbol: APH1A)
Molecule annotation
1
Gamma-secretase Subunit Pen-2
(Gene symbol: PSENEN)
Molecule annotation
Chemicals and Non-standard biopolymers (22 molecules)
1
17
N-ACETYL-D-GLUCOSAMINEN-ACETYL-D-GLUCOSAMINE
2
3
BETA-D-MANNOSEBETA-D-MANNOSE
3
2
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303