5FXS: IGFR-1R complex with a pyrimidine inhibitor

PDB ID: 5FXSDownload
MMDB ID: 144104
PDB Deposition Date: 2016/3/2
Updated in MMDB: 2016/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 5FXS: monomeric; determined by author and by software (PISA)
Molecular Components in 5FXS
Label Count Molecule
Protein (1 molecule)
1
Insulin-like Growth Factor 1 Receptor
(Gene symbol: IGF1R)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
3
ACETATE IONACETATE ION
2
1
2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303