5GMK: Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom resolution

PDB ID: 5GMKDownload
MMDB ID: 142536
PDB Deposition Date: 2016/7/14
Updated in MMDB: 2016/12
Experimental Method:
electron microscopy
Resolution: 3.4  Å
Source Organism:
Similar Structures:
Biological Unit for 5GMK: 45-meric; determined by author
Molecular Components in 5GMK
Label Count Molecule
Proteins (39 molecules)
1
Pre-mrna-splicing Factor 8
(Gene symbol: PRP8)
Molecule annotation
1
Pre-mrna-splicing Factor Snu114
(Gene symbol: SNU114)
Molecule annotation
1
Pre-mrna-splicing Factor Cwc21
(Gene symbol: CWC21)
Molecule annotation
1
Pre-mrna-splicing Factor Prp46
(Gene symbol: PRP46)
Molecule annotation
1
Pre-mrna-processing Protein 45
(Gene symbol: PRP45)
Molecule annotation
1
Pre-mrna-splicing Factor Slt11
(Gene symbol: ECM2)
Molecule annotation
1
Pre-mrna-splicing Factor Cwc2
(Gene symbol: CWC2)
Molecule annotation
1
Pre-mrna-splicing Factor Cwc15
(Gene symbol: CWC15)
Molecule annotation
1
Pre-mrna-splicing Factor Bud31
(Gene symbol: BUD31)
Molecule annotation
1
Pre-mrna-splicing Factor Cwc22
(Gene symbol: CWC22)
Molecule annotation
1
Pre-mrna-splicing Factor Cef1
(Gene symbol: CEF1)
Molecule annotation
1
Pre-mrna-splicing Factor Clf1
(Gene symbol: CLF1)
Molecule annotation
1
Protein Cwc16
(Gene symbol: YJU2)
Molecule annotation
1
Pre-mrna-splicing Factor Cwc25
(Gene symbol: CWC25)
Molecule annotation
1
Pre-mrna-splicing Factor Isy1
(Gene symbol: ISY1)
Molecule annotation
1
Pre-mrna-splicing Factor Syf2
(Gene symbol: SYF2)
Molecule annotation
1
Pre-mrna-splicing Factor Syf1
(Gene symbol: SYF1)
Molecule annotation
1
Pre-mrna-processing Factor 17
(Gene symbol: CDC40)
Molecule annotation
4
Pre-mrna-processing Factor 19
(Gene symbol: PRP19)
Molecule annotation
1
Pre-mrna-splicing Factor Snt309
(Gene symbol: SNT309)
Molecule annotation
2
Small Nuclear Ribonucleoprotein-associated Protein B
(Gene symbol: SMB1)
Molecule annotation
2
Small Nuclear Ribonucleoprotein E
(Gene symbol: SME1)
Molecule annotation
2
Small Nuclear Ribonucleoprotein F
(Gene symbol: SMX3)
Molecule annotation
2
Small Nuclear Ribonucleoprotein G
(Gene symbol: SMX2)
Molecule annotation
2
Small Nuclear Ribonucleoprotein SM D3
(Gene symbol: SMD3)
Molecule annotation
2
Small Nuclear Ribonucleoprotein SM D1
(Gene symbol: SMD1)
Molecule annotation
2
Small Nuclear Ribonucleoprotein SM D2
(Gene symbol: SMD2)
Molecule annotation
1
U2 Small Nuclear Ribonucleoprotein B''
(Gene symbol: MSL1)
Molecule annotation
1
U2 Small Nuclear Ribonucleoprotein A'
(Gene symbol: LEA1)
Molecule annotation
Nucleotides(6 molecules)
1
U5 Snrna
Molecule annotation
1
U6 Snrna
Molecule annotation
1
U2 Snrna
Molecule annotation
1
Intron_bps
Molecule annotation
1
5'-exon
Molecule annotation
1
5'-splicing Site
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
1
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
2
6
MAGNESIUM IONMAGNESIUM ION
3
7
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303