5IJ8: Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor

PDB ID: 5IJ8Download
MMDB ID: 138990
PDB Deposition Date: 2016/3/1
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.99  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 5IJ8: trimeric; determined by author and by software (PISA)
Molecular Components in 5IJ8
Label Count Molecule
Proteins (3 molecules)
1
Enhancer of Zeste Homolog 2 (Ezh2),histone-lysine N-methyltransferase Ezh2
Molecule annotation
1
Polycomb Protein EED
Molecule annotation
1
Polycomb Protein Suz12
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
1
5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one
2
7
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303