5J6A: Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS46

PDB ID: 5J6ADownload
MMDB ID: 146781
PDB Deposition Date: 2016/4/4
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.045  Å
Source Organism:
Similar Structures:
Biological Unit for 5J6A: dimeric; determined by author and by software (PISA)
Molecular Components in 5J6A
Label Count Molecule
Proteins (2 molecules)
2
[pyruvate Dehydrogenase (Acetyl-transferring)] Kinase Isozyme 2, Mitochondrial
(Gene symbol: PDK2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
(3S)-3-amino-4-[4-({2-[(2,4-dihydroxyphenyl)sulfonyl]-2H-isoindol-5-yl}amino)piperidin-1-yl]-4-oxobutanamide(3S)-3-amino-4-[4-({2-[(2,4-dihydroxyphenyl)sulfonyl]-2H-isoindol-5-yl}amino)piperidin-1-yl]-4-oxobutanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303