5JRQ: BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM

PDB ID: 5JRQDownload
MMDB ID: 143094
PDB Deposition Date: 2016/5/6
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 2.287  Å
Source Organism:
Similar Structures:
Biological Unit for 5JRQ: dimeric; determined by author
Molecular Components in 5JRQ
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase B-raf
(Gene symbol: BRAF)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
N-{2,4-difluoro-3-[5-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamideN-{2,4-difluoro-3-[5-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamide
2
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
GLYCEROLGLYCEROL
4
2
TETRAMETHYLAMMONIUM IONTETRAMETHYLAMMONIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303