National Center for
Biotechnology Information

5LDW: Structure of mammalian respiratory Complex I, class1

PDB ID:	5LDW Download
MMDB ID:	180796
PDB Deposition Date:	2016/6/28
Updated in MMDB:	2022/11
Experimental Method:	electron microscopy
Resolution:	4.27 Å
Source Organism:	Bos taurus
Similar Structures:

Biological Unit for 5LDW: 45-meric; determined by software (PISA)

Molecular Components in 5LDW
Label	Count	Molecule
Proteins (45 molecules)
A	1	Nadh-ubiquinone Oxidoreductase Chain 3 (Gene symbol: ND3)
B	1	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 7, Mitochondrial (Gene symbol: NDUFS7)
C	1	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 3, Mitochondrial (Gene symbol: NDUFS3)
D	1	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 2, Mitochondrial (Gene symbol: NDUFS2)
E	1	Nadh Dehydrogenase [ubiquinone] Flavoprotein 2, Mitochondrial (Gene symbol: NDUFV2)
F	1	Nadh Dehydrogenase [ubiquinone] Flavoprotein 1, Mitochondrial (Gene symbol: NDUFV1)
G	1	Nadh-ubiquinone Oxidoreductase 75 KDA Subunit, Mitochondrial,nadh-ubiquinone Oxidoreductase 75 KDA Subunit, Mitochondrial (Gene symbol: NDUFS1)
H	1	Nadh-ubiquinone Oxidoreductase Chain 1
I	1	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 8, Mitochondrial (Gene symbol: NDUFS8)
J	1	Nadh-ubiquinone Oxidoreductase Chain 6 (Gene symbol: ND6)
K	1	Nadh-ubiquinone Oxidoreductase Chain 4L (Gene symbol: ND4L)
L	1	Nadh-ubiquinone Oxidoreductase Chain 5
M	1	Nadh-ubiquinone Oxidoreductase Chain 4 (Gene symbol: ND4)
N	1	Nadh-ubiquinone Oxidoreductase Chain 2
O	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 10, Ndufa10,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 10, Ndufa10,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 10, Mitochondrial (Gene symbol: NDUFA10)
P	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 9, Ndufa9
Q	1	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 4, Ndufs4
R	1	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 6, Ndufs6,nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 6, Mitochondrial,nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 6, Mitochondrial (Gene symbol: NDUFS6)
S	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 2 (Gene symbol: NDUFA2)
T U	2	Acyl Carrier Protein, Mitochondrial (Gene symbol: NDUFAB1)
V	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 5 (Gene symbol: NDUFA5)
W	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 6 (Gene symbol: NDUFA6)
X	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 8,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 8,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 8, Ndufa8 (Gene symbol: NDUFA8)
Y	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 11 (Gene symbol: NDUFA11)
Z	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 13, Ndufa13,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 13,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 13, Ndufa13,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 13,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 13, Ndufa13,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 13,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 13, Ndufa13 (Gene symbol: NDUFA13)
a	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 1 (Gene symbol: NDUFA1)
b	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 3,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 3,nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 3, Ndufa3 (Gene symbol: NDUFA3)
c	1	Nadh Dehydrogenase [ubiquinone] 1 Subunit C1, Mitochondrial (Gene symbol: NDUFC1)
d	1	Nadh Dehydrogenase [ubiquinone] 1 Subunit C2, Ndufc2,nadh Dehydrogenase [ubiquinone] 1 Subunit C2,nadh Dehydrogenase [ubiquinone] 1 Subunit C2, Ndufc2,nadh Dehydrogenase [ubiquinone] 1 Subunit C2,nadh Dehydrogenase [ubiquinone] 1 Subunit C2, Ndufc2,nadh Dehydrogenase [ubiquinone] 1 Subunit C2,nadh Dehydrogenase [ubiquinone] 1 Subunit C2, Ndufc2 (Gene symbol: NDUFC2)
e	1	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 5 (Gene symbol: NDUFS5)
f	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 1 (Gene symbol: NDUFB1)
g	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 11, Mitochondrial (Gene symbol: NDUFB11)
h	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 5, Ndufb5 (Gene symbol: NDUFB5)
i	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 6,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 6,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 6, Ndufb6 (Gene symbol: NDUFB6)
j	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 2, Ndufb2
k	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 3, Ndufb3
l	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 8, Ndufb8
m	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 4, Ndufb4,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 4, Ndufb4,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 4 (Gene symbol: NDUFB4)
n	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 9,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 9,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 9, Ndufb9 (Gene symbol: NDUFB9)
o	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 7 (Gene symbol: NDUFB7)
p	1	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 10, Ndufb10,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 10,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 10, Ndufb10,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 10,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 10, Ndufb10,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 10,nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 10, Ndufb10 (Gene symbol: NDUFB10)
q	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 12 (Gene symbol: NDUFA12)
r	1	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 7, Ndufa7
s	1	Nadh Dehydrogenase [ubiquinone] Flavoprotein 3, Ndufv3
Chemicals and Non-standard biopolymers (11 molecules)
1	6	IRON/SULFUR CLUSTER (Link to PubChem not yet available)
2	2	FE2/S2 (INORGANIC) CLUSTER (Link to PubChem not yet available)
3	1	FLAVIN MONONUCLEOTIDE (Link to PubChem not yet available)
4	1	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (Link to PubChem not yet available)
5	1	ZINC ION (Link to PubChem not yet available)

* Click molecule labels to explore molecular sequence information.

Citing MMDB

Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303