5T7O: Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE

PDB ID: 5T7ODownload
MMDB ID: 154630
PDB Deposition Date: 2016/9/5
Updated in MMDB: 2019/10
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 5T7O: dimeric; determined by software (PISA)
Molecular Components in 5T7O
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Dihydrofolate Reductase-thymidylate Synthase
(Gene symbol: Tc00.1047053509153.90)
Molecule annotation
Chemicals and Non-standard biopolymers (37 molecules)
1
2
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
2
(6S)-5,6,7,8-TETRAHYDROFOLATE(6S)-5,6,7,8-TETRAHYDROFOLATE
3
2
2'-DEOXYURIDINE 5'-MONOPHOSPHATE2'-DEOXYURIDINE 5'-MONOPHOSPHATE
4
31
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303