5X67: Human thymidylate synthase in complex with dUMP and nolatrexed

PDB ID: 5X67Download
MMDB ID: 152318
PDB Deposition Date: 2017/2/21
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.13  Å
Source Organism:
Similar Structures:
Biological Unit for 5X67: dimeric; determined by author and by software (PISA)
Molecular Components in 5X67
Label Count Molecule
Proteins (2 molecules)
2
Thymidylate Synthase
(Gene symbol: TYMS)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
2'-DEOXYURIDINE 5'-MONOPHOSPHATE2'-DEOXYURIDINE 5'-MONOPHOSPHATE
2
2
2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303