5ZJ6: Crystal structure of HCK kinase complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

PDB ID: 5ZJ6Download
MMDB ID: 162960
PDB Deposition Date: 2018/3/19
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.696  Å
Source Organism:
Similar Structures:
Biological Unit for 5ZJ6: dimeric; determined by author
Molecular Components in 5ZJ6
Label Count Molecule
Proteins (2 molecules)
2
Tyrosine-protein Kinase HCK
(Gene symbol: HCK)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303