6HUP: CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38

PDB ID: 6HUPDownload
MMDB ID: 170219
PDB Deposition Date: 2018/10/9
Updated in MMDB: 2023/11
Experimental Method:
electron microscopy
Resolution: 3.58  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 6HUP: hexameric; determined by author and by software (PISA)
Molecular Components in 6HUP
Label Count Molecule
Proteins (6 molecules)
2
Gamma-aminobutyric Acid Receptor Subunit Alpha-1,gamma-aminobutyric Acid Receptor Subunit Alpha-1
Molecule annotation
2
Gamma-aminobutyric Acid Receptor Subunit Beta-3
Molecule annotation
1
Gamma-aminobutyric Acid Receptor Subunit Gamma-2
Molecule annotation
1
Megabody Mb38
Molecule annotation
Chemicals and Non-standard biopolymers (37 molecules)
1
14
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
beta-D-mannopyranosebeta-D-mannopyranose
3
12
alpha-D-mannopyranosealpha-D-mannopyranose
4
2
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
5
2
GAMMA-AMINO-BUTANOIC ACIDGAMMA-AMINO-BUTANOIC ACID
6
3
7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303