6IDF: Cryo-EM structure of gamma secretase in complex with a Notch fragment

PDB ID: 6IDFDownload
MMDB ID: 170113
PDB Deposition Date: 2018/9/9
Updated in MMDB: 2018/12
Experimental Method:
electron microscopy
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 6IDF: pentameric; determined by author
Molecular Components in 6IDF
Label Count Molecule
Proteins (5 molecules)
1
Nicastrin
(Gene symbol: NCSTN)
Molecule annotation
1
Presenilin-1
(Gene symbol: PSEN1)
Molecule annotation
1
Gamma-secretase Subunit Aph-1a
(Gene symbol: APH1A)
Molecule annotation
1
Gamma-secretase Subunit Pen-2
(Gene symbol: PSENEN)
Molecule annotation
1
Notch1
Molecule annotation
Chemicals and Non-standard biopolymers (28 molecules)
1
18
N-ACETYL-D-GLUCOSAMINEN-ACETYL-D-GLUCOSAMINE
2
3
BETA-D-MANNOSEBETA-D-MANNOSE
3
4
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
4
3
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303