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6IYC:
Recognition of the Amyloid Precursor Protein by Human gamma-secretase
PDB ID:
6IYC
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MMDB ID:
170731
PDB Deposition Date:
2018/12/14
Updated in MMDB:
2019/11
Experimental Method:
electron microscopy
Resolution:
2.6 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 6IYC: pentameric; determined by author
Molecular Components in 6IYC
Label
Count
Molecule
Proteins (5 molecules)
A
1
Nicastrin
(Gene symbol:
NCSTN
)
B
1
Presenilin-1
(Gene symbol:
PSEN1
)
C
1
Gamma-secretase Subunit Aph-1a
(Gene symbol:
APH1A
)
D
1
Gamma-secretase Subunit Pen-2
(Gene symbol:
PSENEN
)
E
1
Amyloid-beta A4 Protein
(Gene symbol:
APP
)
Chemicals and Non-standard biopolymers (26 molecules)
1
18
N-ACETYL-D-GLUCOSAMINE
2
3
BETA-D-MANNOSE
3
2
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
4
3
CHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303