6LR4: Molecular basis for inhibition of human gamma-secretase by small molecule

PDB ID: 6LR4Download
MMDB ID: 197860
PDB Deposition Date: 2020/1/15
Updated in MMDB: 2021/01
Experimental Method:
electron microscopy
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 6LR4: tetrameric; determined by author
Molecular Components in 6LR4
Label Count Molecule
Proteins (4 molecules)
1
Nicastrin
(Gene symbol: NCSTN)
Molecule annotation
1
Presenilin-1
(Gene symbol: PSEN1)
Molecule annotation
1
Gamma-secretase Subunit Aph-1a
(Gene symbol: APH1A)
Molecule annotation
1
Gamma-secretase Subunit Pen-2
(Gene symbol: PSENEN)
Molecule annotation
Chemicals and Non-standard biopolymers (27 molecules)
1
18
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
beta-D-mannopyranosebeta-D-mannopyranose
3
2
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
4
1
(2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide(2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide
5
3
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303