6PP9: Crystal structure of BRAF:MEK1 complex

PDB ID: 6PP9Download
MMDB ID: 180314
PDB Deposition Date: 2019/7/5
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 2.59  Å
Source Organism:
Similar Structures:
Biological Unit for 6PP9: dimeric; determined by author and by software (PISA)
Molecular Components in 6PP9
Label Count Molecule
Proteins (2 molecules)
1
Serine/threonine-protein Kinase B-raf
(Gene symbol: BRAF)
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
(Gene symbol: MAP2K1)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
2
MAGNESIUM IONMAGNESIUM ION
3
2
CHLORIDE IONCHLORIDE ION
4
1
5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
5
1
SULFATE IONSULFATE ION
6
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303