6R2W: Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor

PDB ID: 6R2WDownload
MMDB ID: 182165
PDB Deposition Date: 2019/3/19
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.25  Å
Source Organism:
Similar Structures:
Biological Unit for 6R2W: trimeric; determined by author and by software (PISA)
Molecular Components in 6R2W
Label Count Molecule
Proteins (3 molecules)
1
Coagulation Factor VII
(Gene symbol: F7)
Molecule annotation
1
Coagulation Factor VII
(Gene symbol: F7)
Molecule annotation
1
Tissue Factor
(Gene symbol: F3)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
1
beta-D-glucopyranosebeta-D-glucopyranose
2
2
alpha-D-xylopyranosealpha-D-xylopyranose
3
9
CALCIUM IONCALCIUM ION
4
1
alpha-L-fucopyranosealpha-L-fucopyranose
5
10
TETRAMETHYLAMMONIUM IONTETRAMETHYLAMMONIUM ION
6
1
N-acetyl-D-phenylalanyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamideN-acetyl-D-phenylalanyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303