6R6H: Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome

PDB ID: 6R6HDownload
MMDB ID: 247409
PDB Deposition Date: 2019/3/27
Updated in MMDB: 2024/05
Experimental Method:
electron microscopy
Resolution: 8.4  Å
Source Organism:
Similar Structures:
Biological Unit for 6R6H: tridecameric; determined by author
Molecular Components in 6R6H
Label Count Molecule
Proteins (13 molecules)
1
Cop9 Signalosome Complex Subunit 1
(Gene symbol: GPS1)
Molecule annotation
1
Cop9 Signalosome Complex Subunit 2
(Gene symbol: COPS2)
Molecule annotation
1
Cop9 Signalosome Complex Subunit 3
(Gene symbol: COPS3)
Molecule annotation
1
Cop9 Signalosome Complex Subunit 4
(Gene symbol: COPS4)
Molecule annotation
1
Cop9 Signalosome Complex Subunit 5
(Gene symbol: COPS5)
Molecule annotation
1
Cop9 Signalosome Complex Subunit 6
(Gene symbol: COPS6)
Molecule annotation
1
Cop9 Signalosome Complex Subunit 8
(Gene symbol: COPS8)
Molecule annotation
1
Cullin-2
(Gene symbol: CUL2)
Molecule annotation
1
Elongin-b
(Gene symbol: ELOB)
Molecule annotation
1
Eloc_human
Molecule annotation
1
Rbx1_human
Molecule annotation
1
VON Hippel-lindau Disease Tumor Suppressor
(Gene symbol: VHL)
Molecule annotation
1
Cop9 Signalosome Complex Subunit 7B
(Gene symbol: COPS7B)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303