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6TAN:
X-RAY STRUCTURE OF HUMAN K-RAS G12C IN COMPLEX WITH COVALENT ISOQUINOLINONE INHIBITOR (COMPOUND 17)
PDB ID:
6TAN
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MMDB ID:
186140
PDB Deposition Date:
2019/10/30
Updated in MMDB:
2020/06
Experimental Method:
x-ray diffraction
Resolution:
1.16 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 6TAN: monomeric; determined by author and by software (PISA)
Molecular Components in 6TAN
Label
Count
Molecule
Protein (1 molecule)
A
1
Gtpase Kras
(Gene symbol:
KRAS
)
Chemicals and Non-standard biopolymers (3 molecules)
1
1
GUANOSINE-5'-DIPHOSPHATE
2
1
MAGNESIUM ION
3
1
7-(2-fluoranyl-6-oxidanyl-phenyl)-3-[(3~{R})-1-propanoylpyrrolidin-3-yl]-4~{H}-2,6-naphthyridin-1-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303