6TM5: Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate at 3.9 angstrom resolution

PDB ID: 6TM5Download
MMDB ID: 184442
PDB Deposition Date: 2019/12/3
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.9  Å
Source Organism:
Similar Structures:
Biological Unit for 6TM5: 22-meric; determined by author
Molecular Components in 6TM5
Label Count Molecule
Proteins (22 molecules)
1
Anaphase-promoting Complex Subunit 1
(Gene symbol: ANAPC1)
Molecule annotation
1
Anaphase-promoting Complex Subunit 11
(Gene symbol: ANAPC11)
Molecule annotation
2
Cell Division Cycle Protein 23 Homolog
(Gene symbol: CDC23)
Molecule annotation
1
Anaphase-promoting Complex Subunit 15
(Gene symbol: ANAPC15)
Molecule annotation
1
Anaphase-promoting Complex Subunit 16
(Gene symbol: ANAPC16)
Molecule annotation
2
Cell Division Cycle Protein 27 Homolog
(Gene symbol: CDC27)
Molecule annotation
2
Anaphase-promoting Complex Subunit Cdc26
(Gene symbol: CDC26)
Molecule annotation
1
Anaphase-promoting Complex Subunit 4
(Gene symbol: ANAPC4)
Molecule annotation
2
Cell Division Cycle Protein 16 Homolog
(Gene symbol: CDC16)
Molecule annotation
1
Anaphase-promoting Complex Subunit 10
(Gene symbol: ANAPC10)
Molecule annotation
1
Anaphase-promoting Complex Subunit 13
(Gene symbol: ANAPC13)
Molecule annotation
1
Anaphase-promoting Complex Subunit 2
(Gene symbol: ANAPC2)
Molecule annotation
1
Anaphase-promoting Complex Subunit 5
(Gene symbol: ANAPC5)
Molecule annotation
1
Apc1 Loop
Molecule annotation
2
Anaphase-promoting Complex Subunit 7
(Gene symbol: ANAPC7)
Molecule annotation
1
Serine/threonine-protein Kinase Nek2
(Gene symbol: NEK2)
Molecule annotation
1
Serine/threonine-protein Kinase Nek2
(Gene symbol: NEK2)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
3
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303