6TWF: Human CD73 (ecto 5'-nucleotidase) in complex with PSB12604 (an AOPCP derivative, compound 21 in publication) in the closed state

PDB ID: 6TWFDownload
MMDB ID: 184454
PDB Deposition Date: 2020/1/13
Updated in MMDB: 2020/04
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 6TWF: dimeric; determined by author and by software (PISA)
Molecular Components in 6TWF
Label Count Molecule
Proteins (2 molecules)
2
5'-nucleotidase
(Gene symbol: NT5E)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
4
ZINC IONZINC ION
2
2
CALCIUM IONCALCIUM ION
3
2
[[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-2-piperazin-4-ium-1-yl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid[[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-2-piperazin-4-ium-1-yl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303