7M66: Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor

PDB ID: 7M66Download
MMDB ID: 220661
PDB Deposition Date: 2021/3/25
Updated in MMDB: 2022/10
Experimental Method:
x-ray diffraction
Resolution: 2.25  Å
Source Organism:
Similar Structures:
Biological Unit for 7M66: dimeric; determined by author and by software (PISA)
Molecular Components in 7M66
Label Count Molecule
Proteins (2 molecules)
2
Hydroxymethylglutaryl-coa Reductase, Degradative
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
1
SULFATE IONSULFATE ION
2
3
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
3
3
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
4
5
CALCIUM IONCALCIUM ION
5
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303