7R0M: KRasG12C in complex with GDP and JDQ443

PDB ID: 7R0MDownload
MMDB ID: 214805
PDB Deposition Date: 2022/2/2
Updated in MMDB: 2022/06
Experimental Method:
x-ray diffraction
Resolution: 1.611  Å
Source Organism:
Similar Structures:
Biological Unit for 7R0M: monomeric; determined by author
Molecular Components in 7R0M
Label Count Molecule
Protein (1 molecule)
1
Gtpase Kras
(Gene symbol: KRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
MAGNESIUM IONMAGNESIUM ION
2
2
1-[6-[4-(5-chloranyl-6-methyl-1~{H}-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]propan-1-one1-[6-[4-(5-chloranyl-6-methyl-1~{H}-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]propan-1-one
3
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303