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Biotechnology Information

8C3A: Crystal structure of ailanthone bound to the Candida albicans 80S ribosome

PDB ID:	8C3A Download
MMDB ID:	240947
PDB Deposition Date:	2022/12/23
Updated in MMDB:	2024/01
Experimental Method:	x-ray diffraction
Resolution:	3 Å
Source Organism:	Candida albicans
Similar Structures:

Biological Unit for 8C3A: 163-meric; determined by author

Molecular Components in 8C3A
Label	Count	Molecule
Proteins (155 molecules)
j AW	2	60S Ribosomal Protein L2-b
k AX	2	60S Ribosomal Protein L3
l AY	2	60S Ribosomal Protein L4-b
m AZ	2	Uncharacterized Protein Caj7.0206
n BA	2	60S Ribosomal Protein L6
o BB	2	60S Ribosomal Protein L7-a
p BC	2	60S Ribosomal Protein L8
q BD	2	60S Ribosomal Protein L9-b
r BE	2	60S Ribosomal Protein L10
s BF	2	60S Ribosomal Protein L11-b
t BG	2	60S Ribosomal Protein L13
u BH	2	60S Ribosomal Protein L14-b
v BI	2	60S Ribosomal Protein L15-a
w BJ	2	Ribosomal Protein L13
x BK	2	Ribosomal Protein L22
y BL	2	60S Ribosomal Protein L18-a
z BM	2	60S Ribosomal Protein L19-a
0 BN	2	60S Ribosomal Protein L20
2 BO	2	60S Ribosomal Protein L21-a
5 BP	2	60S Ribosomal Protein L22-b
6 BQ	2	60S Ribosomal Protein L23-a
7 BR	2	60S Ribosomal Protein L24-a
8 BS	2	60S Ribosomal Protein L25
9 BT	2	Ribosomal Protein L24
AA BU	2	60S Ribosomal Protein L27
AB BV	2	60S Ribosomal Protein L28
AC BW	2	60S Ribosomal Protein L29
AD BX	2	60S Ribosomal Protein L30
AE BY	2	60S Ribosomal Protein L31-b
AF BZ	2	60S Ribosomal Protein L32
AG CA	2	60S Ribosomal Protein L33-a
AH CB	2	60S Ribosomal Protein L34-b
AI CC	2	Ribosomal Protein L29
AJ CD	2	60S Ribosomal Protein L36
AK CE	2	60S Ribosomal Protein L37-b
AL CF	2	60S Ribosomal Protein L38
AM CG	2	60S Ribosomal Protein L39
AN CH	2	60S Ribosomal Protein L40-b
AO CI	2	60S Ribosomal Protein L41
AP CJ	2	60S Ribosomal Protein L42-b
AQ CK	2	60S Ribosomal Protein L43-a
i CL	2	60S Ribosomal Protein Caalfm_c304810ca
C CN	2	40S Ribosomal Protein S0
D CO	2	40S Ribosomal Protein S1
E CP	2	Ribosomal Protein S5
F CQ	2	Ribosomal Protein S3
G CR	2	40S Ribosomal Protein S4
H CS	2	Ribosomal Protein S7
I CT	2	40S Ribosomal Protein S6
J CU	2	40S Ribosomal Protein S7
K CV	2	40S Ribosomal Protein S8
L CW	2	Ribosomal Protein S4
M CX	2	40S Ribosomal Protein S10-a
N CY	2	40S Ribosomal Protein S11a
O CZ	2	40S Ribosomal Protein S12
P DA	2	40S Ribosomal Protein S13
Q DB	2	40S Ribosomal Protein S14-a
R DC	2	40S Ribosomal Protein S15
S DD	2	40S Ribosomal Protein S16
T DE	2	40S Ribosomal Protein S17-b
U DF	2	40S Ribosomal Protein S18-b
V DG	2	40S Ribosomal Protein S19-a
W DH	2	Ribosomal Protein S10
X DI	2	40S Ribosomal Protein S21
Y DJ	2	40S Ribosomal Protein S22-a
Z DK	2	Ribosomal Protein S23 (S12)
a DL	2	40S Ribosomal Protein S24
b DM	2	40S Ribosomal Protein S25
c DN	2	40S Ribosomal Protein S26
d DO	2	40S Ribosomal Protein S27
e DP	2	40S Ribosomal Protein S28-b
f DQ	2	40S Ribosomal Protein S29a
g DR	2	40S Ribosomal Protein S30
h DS	2	Ubiquitin-40s Ribosomal Protein S31 Fusion Protein
AR DT	2	Guanine Nucleotide-binding Protein Subunit Beta-like Protein
P0 p0	2	60S Acidic Ribosomal Protein P0
12	1	60S Ribosomal Protein L12-a
L1 l1	2	Ribosomal Protein
Nucleotides(8 molecules)
1 AS	2	25S
3 AT	2	5S
4 AU	2	5.8s
B CM	2	18S
Chemicals and Non-standard biopolymers (1452 molecules)
1	1430	MAGNESIUM ION
2	2	3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose
3	2	ailanthone
4	18	ZINC ION

* Click molecule labels to explore molecular sequence information.

Citing MMDB

Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303