8E5M: Structure of ARG1 complex with pyrrolidine-based non-boronic acid inhibitor 6

PDB ID: 8E5MDownload
MMDB ID: 227633
PDB Deposition Date: 2022/8/22
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.84  Å
Source Organism:
Similar Structures:
Biological Unit for 8E5M: trimeric; determined by author and by software (PISA)
Molecular Components in 8E5M
Label Count Molecule
Proteins (3 molecules)
3
Arginase-1
(Gene symbol: ARG1)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
6
MANGANESE (II) IONMANGANESE (II) ION
2
3
1-{[(3S,4S)-3-({4-[2-(4-fluorobenzene-1-sulfonyl)ethyl]piperidin-1-yl}methyl)-4-(3-fluorophenyl)pyrrolidin-1-yl]methyl}cyclopentane-1-carboxylic acid1-{[(3S,4S)-3-({4-[2-(4-fluorobenzene-1-sulfonyl)ethyl]piperidin-1-yl}methyl)-4-(3-fluorophenyl)pyrrolidin-1-yl]methyl}cyclopentane-1-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303