8FC7: Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745

PDB ID: 8FC7Download
MMDB ID: 232793
PDB Deposition Date: 2022/12/1
Updated in MMDB: 2023/07
Experimental Method:
electron microscopy
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 8FC7: octameric; determined by author
Molecular Components in 8FC7
Label Count Molecule
Proteins (8 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 4
(Gene symbol: TRPV4)
Molecule annotation
4
Transforming Protein Rhoa
(Gene symbol: RHOA)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
4
1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile
2
4
MAGNESIUM IONMAGNESIUM ION
3
4
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303