NCBI
National Center for
Biotechnology Information
Search
8TBU:
Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator Compound 12
PDB ID:
8TBU
Download
MMDB ID:
240685
PDB Deposition Date:
2023/6/29
Updated in MMDB:
2023/12
Experimental Method:
x-ray diffraction
Resolution:
2.35 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 8TBU: tetrameric; determined by author and by software (PISA)
Molecular Components in 8TBU
Label
Count
Molecule
Proteins (4 molecules)
A
B
C
D
4
Pyruvate Kinase Pklr
(Gene symbol:
PKLR
)
Chemicals and Non-standard biopolymers (15 molecules)
1
2
6-[(4-hydroxyphenyl)methyl]-2,4-dimethyl-4,6-dihydro-5H-[1,3]thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5-one
2
3
PYRUVIC ACID
3
4
1,6-di-O-phosphono-beta-D-fructofuranose
4
4
MANGANESE (II) ION
5
2
POTASSIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303