Table 1.

The FDA (2018) Drug Label for Esomeprazole: CYP2C19

PhenotypeEsomeprazole
CYP2C19 poor metabolizerThe CYP2C19 isoenzyme exhibits polymorphism in the metabolism of esomeprazole, since some 3% of Caucasians and 15–20% of Asians lack CYP2C19 and are termed poor metabolizers. At steady state, the ratio of AUC in poor metabolizers to AUC in the rest of the population (normal metabolizers) is approximately 2.

AUC: Area Under the plasma drug concentration-time Curve. AUC reflects the body’s exposure to the drug being administered.
Note: “normal metabolizers” were previously termed “extensive metabolizers”.

Please see Therapeutic Recommendations based on Genotype for more information from FDA. This FDA table is adapted from (1).

From: Esomeprazole Therapy and CYP2C19 Genotype

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Pratt VM, Scott SA, Pirmohamed M, et al., editors.
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