Table 5b.

X-Linked Neutropenia: Treatment of Manifestations

Manifestation/ConcernTreatmentConsiderations/Other
Neutropenia / Recurrent bacterial infections
  • G-CSF therapy
  • Consider prophylactic antibiotics in persons w/recurrent bacterial sinopulmonary infections.
  • Routine immunizations. "Non-live" vaccinations can be given safely to persons w/a WAS-related disorder but may not generate protective levels of antibodies.
Infection
  • Prompt eval & treatment for infection
  • Treatment w/empiric parenteral antibiotics is necessary in most persons.
  • Exhaustive eval for source of infection, which may incl invasive assessments; identification of offending organism is needed to guide therapy.
Myelodysplastic syndrome / AML Treatment per hematologist/oncologist

G-CSF = granulocyte colony-stimulating factor

From: WAS-Related Disorders

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