Table 10.

Common Cancer-Related PIK3CA Variants Reported in COSMIC Database

Reference SequencesDNA Nucleotide
Change
Predicted
Protein Change
# of Cancer Specimens
with Pathogenic Variant
PIK3CA ENST00000643187
NM_006218​.4
c.1625G>Ap.Glu542Lys633
c.1633G>Ap.Glu545Lys977
c.3140A>Gp.His1047Arg1680
c.3140A>Tp.His1047Leu201

From: PIK3CA-Related Overgrowth Spectrum

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