Table 5Retroviruses Involved in CNS Disease

VirusAnimal(s) affectedTypes of diseaseLatent periodIncidencea(%)References
Cas-Br-E MLVmicespongiform encephalopathy1–8 months70–100 Gardner et al. (1973); Gardner (1978); Portis (1990)
ts1 Mo-MLVmicespongiform encephalopathy1–2 months80–100 Wong et al. (1983); Wong (1990)
ts-BA1 Mo-MLVmicespongiform encephalopathy2.5–5 months80–100 Bilello et al. (1986)
PVC-211rats/micespongiform encephalopathy1 month100 Kai and Furuta (1984)
NT40 MLVratsspongiform encephalopathy4–6 weeks100 Czub et al. (1995)
FMCF98miceastrocyte degeneration1–3 months100 Portis et al. (1995)
TR1.3 MLVmiceintracerebral hemorrhages3 weeks100 Park et al. (1993)
HTLV-1humansmeningomyelitis2–30 years<1 Poiesz et al. (1980); Gessain and Gout (1992)
MVVsheep/goatsencephalomyelitis2–5 years<5 Sigurdsson et al. (1957); Haase (1986)
CAEVkid goatsencephalomyelitis1–6 months20 Cork et al. (1974); McGuire et al. (1990)
FIVcatsencephalopathy2–5 years5 Pedersen et al. (1987); Pedersen (1993)
EIAVhorsesencephalomyelitisunknownsporadic Vallee and Carre (1904); Montelaro et al. (1993)
SIVprimatesencephalopathy<1 year50see Chapter 11
HIVhumansencephalopathy5–10 years25–65see Chapter 11
a

The incidence of disease varies in many cases depending on the strain of animal infected and the titer of virus infecting the host.

(HTLV-1) Human T-cell leukemia virus type 1; (MVV) maedi/visna virus; (CAEV) caprine arthritis encephalitis virus; (FIV) feline immunodeficiency virus; (EIAV) equine infectious anemia virus; (SIV) simian immunodeficiency virus; (HIV) human immunodeficiency virus; (FMCF) Friend mink cell focus-forming virus.

From: Neurological Diseases

Cover of Retroviruses
Retroviruses.
Coffin JM, Hughes SH, Varmus HE, editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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