Table 6.

KCNQ3-Related Disorders: Recommended Surveillance

System/ConcernEvaluationFrequency
Neurologic Monitor w/EEGKCNQ3-SLFNE:
  • EEG at onset & age 3, 12, & 24 mos is recommended.
  • EEG at 24 mos should be normal.
KCNQ3-SLFIE:
  • EEG at onset & age 12, 24, & 36 mos is recommended.
  • The EEG at 36 mos should be normal.
KCNQ3-NDD: sleep EEG at diagnosis is recommended to evaluate presence of sleep-activated epileptic activity.
Assess for new manifestations such as changes in seizure types, changes in tone, & movement disorders.At each visit
Video EEG monitoringWhen new or different seizure types are suspected
Development Monitor developmental progress, communication skills, & educational needs.At each visit
Neurobehavioral/
Psychiatric 		Assessment for anxiety, ADHD, ASD, aggression, & self-injury
Family/Community Assess family need for social work support & care coordination.

From: KCNQ3-Related Disorders

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